Maternal age and reproductive function in female Sprague-Dawley rats

Effects of 2-bromopropane on the female reproductive function in Sprague-Dawley rats.

2-Bromopropane (2BP) has been implicated to be the reason for the mass intoxication of workers at an electronic company in Korea. A case series study indicated that 2BP was the possible causative chemical for reproductive toxicity, causing severe anemia accompanied by amenorrhea among female workers, and azoospermia or oligospermia among male workers. To clarify the effect of 2BP on the female ...

Reproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats

The present study was conducted to obtain information on the effects of amitraz on reproductive and developmental parameters in rats. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and up to lactational d...

Reproductive toxic effects of Topamax ingestion in female Sprague-Dawley rats.

PURPOSE The objectives of this study is to investigate the toxic effects of Topamax (100 mg/kg/body weight) on the reproductive system after administration to female Sprague-Dawley rats weighing 250-300 g for two time periods 4 and 12 weeks. METHODS Twenty adult female rats were divided into two groups and exposed to Topiramate diet at a concentration of 100 mg/kg/body weight for two periods ...

Tumor incidence in normal Sprague-Dawley female rats.

Maternal toxicity of methacrylonitrile in Sprague-Dawley rats.

Methacrylonitrile (MeAN) is used in the preparation of plastics, elastomers, homoand copolymers and coatings (Windholz, 1983; Sax and Lewis, 1987) and as a chemical intermediate in the preparation of numerous organic chemicals (Windholz, 1983). MeAN is also used as a replacement for acrylonitrile in the manufacture of carbonated beverage containers (Cosidine, 1974) and is identified as a compon...